Peptidomimetic Escape Mechanisms Arise via Genetic Diversity in the Ligand-Binding Site of the Hepatitis C Virus NS3/4A Serine Protease

BACKGROUND & AIMS: It is a challenge to develop direct-acting antiviral agents (DAAs) that target the NS3/4A protease of hepatitis C virus (HCV) because resistant variants develop. Ketoamide compounds, designed to mimic the natural protease substrate, have been developed as inhibitors. However,...

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Bibliografiske detaljer
Main Authors: Welsch, Christoph, Shimakami, Tetsuro, Hartmann, Christoph, Yang, Yan, Domingues, Francisco S., Lengauer, Thomas, Zeuzem, Stefan, Lemon, Stanley M.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288278/
https://ncbi.nlm.nih.gov/pubmed/22155364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.11.035
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