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Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus

BACKGROUND: The inhibitor telaprevir (VX-950) of the hepatitis C virus (HCV) protease NS3-4A has been tested in a recent phase 1b clinical trial in patients infected with HCV genotype 1. This trial revealed residue mutations that confer varying degrees of drug resistance. In particular, two protease...

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Bibliografski detalji
Glavni autori: Welsch, Christoph, Domingues, Francisco S, Susser, Simone, Antes, Iris, Hartmann, Christoph, Mayr, Gabriele, Schlicker, Andreas, Sarrazin, Christoph, Albrecht, Mario, Zeuzem, Stefan, Lengauer, Thomas
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2395260/
https://ncbi.nlm.nih.gov/pubmed/18215275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2008-9-1-r16
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