Base Pairing between Hepatitis C Virus RNA and MicroRNA 122 3′ of Its Seed Sequence Is Essential for Genome Stabilization and Production of Infectious Virus

MicroRNA 122 (miR-122) facilitates hepatitis C virus (HCV) replication by recruiting an RNA-induced silencing complex (RISC)-like complex containing argonaute 2 (Ago2) to the 5′ end of the HCV genome, thereby stabilizing the viral RNA. This requires base pairing between the miR-122 “seed sequence” (...

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Detalhes bibliográficos
Main Authors: Shimakami, Tetsuro, Yamane, Daisuke, Welsch, Christoph, Hensley, Lucinda, Jangra, Rohit K., Lemon, Stanley M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416334/
https://ncbi.nlm.nih.gov/pubmed/22532678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00513-12
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