Differential hepatitis C virus RNA target site selection and host factor activities of naturally occurring miR-122 3΄ variants

In addition to suppressing cellular gene expression, certain miRNAs potently facilitate replication of specific positive-strand RNA viruses. miR-122, a pro-viral hepatitis C virus (HCV) host factor, binds and recruits Ago2 to tandem sites (S1 and S2) near the 5΄ end of the HCV genome, stabilizing it...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Yamane, Daisuke, Selitsky, Sara R., Shimakami, Tetsuro, Li, You, Zhou, Mi, Honda, Masao, Sethupathy, Praveen, Lemon, Stanley M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5416874/
https://ncbi.nlm.nih.gov/pubmed/28082397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1332
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