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Regulation of Hepatitis C Virus Translation and Infectious Virus Production by the MicroRNA miR-122

miR-122 is a liver-specific microRNA that positively regulates hepatitis C virus (HCV) RNA abundance and is essential for production of infectious HCV. Using a genetic approach, we show that its ability to enhance yields of infectious virus is dependent upon two miR-122-binding sites near the 5′ end...

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Bibliografiske detaljer
Main Authors: Jangra, Rohit K., Yi, MinKyung, Lemon, Stanley M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903297/
https://ncbi.nlm.nih.gov/pubmed/20427538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00417-10
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