Extended interaction networks with HCV protease NS3-4A substrates explain the lack of adaptive capability against protease inhibitors

Inhibitors against the NS3-4A protease of hepatitis C virus (HCV) have proven to be useful drugs in the treatment of HCV infection. Although variants have been identified with mutations that confer resistance to these inhibitors, the mutations do not restore replicative fitness and no secondary muta...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Dultz, Georg, Shimakami, Tetsuro, Schneider, Markus, Murai, Kazuhisa, Yamane, Daisuke, Marion, Antoine, Zeitler, Tobias M., Stross, Claudia, Grimm, Christian, Richter, Rebecca M., Bäumer, Katrin, Yi, MinKyung, Biondi, Ricardo M., Zeuzem, Stefan, Tampé, Robert, Antes, Iris, Lange, Christian M., Welsch, Christoph
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2020
Pynciau:
Microbiology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7535904/
https://ncbi.nlm.nih.gov/pubmed/32747444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013898
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