Extended interaction networks with HCV protease NS3-4A substrates explain the lack of adaptive capability against protease inhibitors

Inhibitors against the NS3-4A protease of hepatitis C virus (HCV) have proven to be useful drugs in the treatment of HCV infection. Although variants have been identified with mutations that confer resistance to these inhibitors, the mutations do not restore replicative fitness and no secondary muta...

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Vydáno v:J Biol Chem
Hlavní autoři: Dultz, Georg, Shimakami, Tetsuro, Schneider, Markus, Murai, Kazuhisa, Yamane, Daisuke, Marion, Antoine, Zeitler, Tobias M., Stross, Claudia, Grimm, Christian, Richter, Rebecca M., Bäumer, Katrin, Yi, MinKyung, Biondi, Ricardo M., Zeuzem, Stefan, Tampé, Robert, Antes, Iris, Lange, Christian M., Welsch, Christoph
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
Microbiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7535904/
https://ncbi.nlm.nih.gov/pubmed/32747444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013898
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