A transcription factor addiction in leukemia imposed by the MLL promoter sequence

The Mixed Lineage Leukemia gene (MLL) is altered in leukemia by chromosomal translocations to produce oncoproteins comprised of the MLL N-terminus fused to the C-terminus of a partner protein. Here, we used domain-focused CRISPR screening to identify ZFP64 as an essential transcription factor in MLL...

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Bibliographic Details
Published in:Cancer Cell
Main Authors: Lu, Bin, Klingbeil, Olaf, Tarumoto, Yusuke, Somerville, Tim D. D., Huang, Yu-Han, Wei, Yiliang, Wai, Dorothy C., Low, Jason K.K., Milazzo, Joseph P., Wu, Xiaoli S., Cao, Zhendong, Yan, Xiaomei, Demerdash, Osama E., Huang, Gang, Mackay, Joel P., Kinney, Justin B., Shi, Junwei, Vakoc, Christopher R.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554023/
https://ncbi.nlm.nih.gov/pubmed/30503706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.10.015
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