Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains

par Shi, Junwei, Wang, Eric, Milazzo, Joseph P., Wang, Zhihua, Kinney, Justin B., Vakoc, Christopher R.
Publié dans Nat Biotechnol (2015)

TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma

par Somerville, Tim D.D., Xu, Yali, Miyabayashi, Koji, Tiriac, Hervé, Cleary, Cristian R., Maia-Silva, Diogo, Milazzo, Joseph P., Tuveson, David A., Vakoc, Christopher R.
Publié dans Cell Rep (2018)

A TFIID-SAGA perturbation that targets MYB and suppresses acute myeloid leukemia

par Xu, Yali, Milazzo, Joseph P., Somerville, Tim D. D., Tarumoto, Yusuke, Huang, Yu-Han, Ostrander, Elizabeth L., Wilkinson, John E., Challen, Grant A., Vakoc, Christopher R.
Publié dans Cancer Cell (2018)

LKB1, Salt-Inducible Kinases, and MEF2C are linked dependencies in acute myeloid leukemia

par Tarumoto, Yusuke, Lu, Bin, Somerville, Tim D. D., Huang, Yu-Han, Milazzo, Joseph P., Wu, Xiaoli S., Klingbeil, Olaf, El Demerdash, Osama, Shi, Junwei, Vakoc, Christopher R.
Publié dans Mol Cell (2018)

Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo

par Tarumoto, Yusuke, Lin, Shan, Wang, Jinhua, Milazzo, Joseph P., Xu, Yali, Lu, Bin, Yang, Zhaolin, Wei, Yiliang, Polyanskaya, Sofya, Wunderlich, Mark, Gray, Nathanael S., Stegmaier, Kimberly, Vakoc, Christopher R.
Publié dans Blood (2020)

POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer

par Huang, Yu-Han, Klingbeil, Olaf, He, Xue-Yan, Wu, Xiaoli S., Arun, Gayatri, Lu, Bin, Somerville, Tim D.D., Milazzo, Joseph P., Wilkinson, John E., Demerdash, Osama E., Spector, David L., Egeblad, Mikala, Shi, Junwei, Vakoc, Christopher R.
Publié dans Genes Dev (2018)

A transcription factor addiction in leukemia imposed by the MLL promoter sequence

par Lu, Bin, Klingbeil, Olaf, Tarumoto, Yusuke, Somerville, Tim D. D., Huang, Yu-Han, Wei, Yiliang, Wai, Dorothy C., Low, Jason K.K., Milazzo, Joseph P., Wu, Xiaoli S., Cao, Zhendong, Yan, Xiaomei, Demerdash, Osama E., Huang, Gang, Mackay, Joel P., Kinney, Justin B., Shi, Junwei, Vakoc, Christopher R.
Publié dans Cancer Cell (2018)

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation

par Shi, Junwei, Whyte, Warren A., Zepeda-Mendoza, Cinthya J., Milazzo, Joseph P., Shen, Chen, Roe, Jae-Seok, Minder, Jessica L., Mercan, Fatih, Wang, Eric, Eckersley-Maslin, Melanie A., Campbell, Amy E., Kawaoka, Shinpei, Shareef, Sarah, Zhu, Zhu, Kendall, Jude, Muhar, Matthias, Haslinger, Christian, Yu, Ming, Roeder, Robert G., Wigler, Michael H., Blobel, Gerd A., Zuber, Johannes, Spector, David L., Young, Richard A., Vakoc, Christopher R.
Publié 2013

Enhancer reprogramming promotes pancreatic cancer metastasis

par Roe, Jae-Seok, Hwang, Chang-Il, Somerville, Tim D.D., Milazzo, Joseph P., Lee, Eun Jung, Da Silva, Brandon, Maiorino, Laura, Tiriac, Hervé, Young, C. Megan, Miyabayashi, Koji, Filippini, Dea, Creighton, Brianna, Burkhart, Richard A., Buscaglia, Jonathan M., Kim, Edward J., Grem, Jean L., Lazenby, Audrey J., Grunkemeyer, James A., Hollingsworth, Michael A., Grandgenett, Paul M., Egeblad, Mikala, Park, Youngkyu, Tuveson, David A., Vakoc, Christopher R.
Publié dans Cell (2017)