A TFIID-SAGA perturbation that targets MYB and suppresses acute myeloid leukemia

Targeting of general coactivators is an emerging strategy to interfere with oncogenic transcription factors (TFs). However, coactivator perturbations are often pleiotropic and influence numerous TFs. Here we identify TAF12, a subunit of TFIID-SAGA coactivator complexes, as a selective requirement fo...

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Vydáno v:Cancer Cell
Hlavní autoři: Xu, Yali, Milazzo, Joseph P., Somerville, Tim D. D., Tarumoto, Yusuke, Huang, Yu-Han, Ostrander, Elizabeth L., Wilkinson, John E., Challen, Grant A., Vakoc, Christopher R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5764110/
https://ncbi.nlm.nih.gov/pubmed/29316427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.12.002
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