Cargando...

Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains

CRISPR-Cas9 genome editing technology holds great promise for discovering therapeutic targets in cancer and other diseases. Current screening strategies target CRISPR-induced mutations to the 5’ exons of candidate genes(1–5), but this approach often produces in-frame variants that retain functionali...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Nat Biotechnol
Main Authors: Shi, Junwei, Wang, Eric, Milazzo, Joseph P., Wang, Zhihua, Kinney, Justin B., Vakoc, Christopher R.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529991/
https://ncbi.nlm.nih.gov/pubmed/25961408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3235
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!