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Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
CRISPR-Cas9 genome editing technology holds great promise for discovering therapeutic targets in cancer and other diseases. Current screening strategies target CRISPR-induced mutations to the 5’ exons of candidate genes(1–5), but this approach often produces in-frame variants that retain functionali...
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| Udgivet i: | Nat Biotechnol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4529991/ https://ncbi.nlm.nih.gov/pubmed/25961408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3235 |
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