A transcription factor addiction in leukemia imposed by the MLL promoter sequence

The Mixed Lineage Leukemia gene (MLL) is altered in leukemia by chromosomal translocations to produce oncoproteins comprised of the MLL N-terminus fused to the C-terminus of a partner protein. Here, we used domain-focused CRISPR screening to identify ZFP64 as an essential transcription factor in MLL...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Cancer Cell
Main Authors: Lu, Bin, Klingbeil, Olaf, Tarumoto, Yusuke, Somerville, Tim D. D., Huang, Yu-Han, Wei, Yiliang, Wai, Dorothy C., Low, Jason K.K., Milazzo, Joseph P., Wu, Xiaoli S., Cao, Zhendong, Yan, Xiaomei, Demerdash, Osama E., Huang, Gang, Mackay, Joel P., Kinney, Justin B., Shi, Junwei, Vakoc, Christopher R.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554023/
https://ncbi.nlm.nih.gov/pubmed/30503706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.10.015
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker