Beyond Blood Smears: Qualification of Plasmodium 18S rRNA as a Biomarker for Controlled Human Malaria Infections

18S rRNA is a biomarker that provides an alternative to thick blood smears in controlled human malaria infection (CHMI) trials. We reviewed data from CHMI trials at non-endemic sites that used blood smears and Plasmodium 18S rRNA/rDNA biomarker nucleic acid tests (NATs) for time to positivity. We va...

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Publicado en:Am J Trop Med Hyg
Main Authors: Seilie, Annette M., Chang, Ming, Hanron, Amelia E., Billman, Zachary P., Stone, Brad C., Zhou, Kevin, Olsen, Tayla M., Daza, Glenda, Ortega, Jose, Cruz, Kurtis R., Smith, Nahum, Healy, Sara A., Neal, Jillian, Wallis, Carolyn K., Shelton, Lisa, Mankowski, Tracie (VonGoedert), Wong-Madden, Sharon, Mikolajczak, Sebastian A., Vaughan, Ashley M., Kappe, Stefan H. I., Fishbaugher, Matt, Betz, Will, Kennedy, Mark, Hume, Jen C. C., Talley, Angela K., Hoffman, Stephen L., Chakravarty, Sumana, Sim, B. Kim Lee, Richie, Thomas L., Wald, Anna, Plowe, Christopher V., Lyke, Kirsten E., Adams, Matthew, Fahle, Gary A., Cowan, Elliot P., Duffy, Patrick E., Kublin, James G., Murphy, Sean C.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society of Tropical Medicine and Hygiene 2019
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6553913/
https://ncbi.nlm.nih.gov/pubmed/31017084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4269/ajtmh.19-0094
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