Beyond Blood Smears: Qualification of Plasmodium 18S rRNA as a Biomarker for Controlled Human Malaria Infections

18S rRNA is a biomarker that provides an alternative to thick blood smears in controlled human malaria infection (CHMI) trials. We reviewed data from CHMI trials at non-endemic sites that used blood smears and Plasmodium 18S rRNA/rDNA biomarker nucleic acid tests (NATs) for time to positivity. We va...

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Vydáno v:Am J Trop Med Hyg
Hlavní autoři: Seilie, Annette M., Chang, Ming, Hanron, Amelia E., Billman, Zachary P., Stone, Brad C., Zhou, Kevin, Olsen, Tayla M., Daza, Glenda, Ortega, Jose, Cruz, Kurtis R., Smith, Nahum, Healy, Sara A., Neal, Jillian, Wallis, Carolyn K., Shelton, Lisa, Mankowski, Tracie (VonGoedert), Wong-Madden, Sharon, Mikolajczak, Sebastian A., Vaughan, Ashley M., Kappe, Stefan H. I., Fishbaugher, Matt, Betz, Will, Kennedy, Mark, Hume, Jen C. C., Talley, Angela K., Hoffman, Stephen L., Chakravarty, Sumana, Sim, B. Kim Lee, Richie, Thomas L., Wald, Anna, Plowe, Christopher V., Lyke, Kirsten E., Adams, Matthew, Fahle, Gary A., Cowan, Elliot P., Duffy, Patrick E., Kublin, James G., Murphy, Sean C.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society of Tropical Medicine and Hygiene 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6553913/
https://ncbi.nlm.nih.gov/pubmed/31017084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4269/ajtmh.19-0094
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