Assay for high-throughput screening of inhibitors of the ASC-PYD inflammasome core filament

The protein ASC is a central component of most inflammasome complexes, forming functional oligomeric filaments that activate large amounts of pro-caspase-1 for further IL-1β processing and the induction of Gasdermin D-dependent cell death. The central role of inflammasomes in the innate immune respo...

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Publicado en:Cell Stress
Autores principales: Sborgi, Lorenzo, Ude, Johanna, Dick, Mathias S., Vesin, Jonathan, Chambon, Marc, Turcatti, Gerardo, Broz, Petr, Hiller, Sebastian
Formato: Artigo
Lenguaje:Inglês
Publicado: Shared Science Publishers OG 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551747/
https://ncbi.nlm.nih.gov/pubmed/31225471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15698/cst2018.04.131
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