Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy

Inflammasomes are multiprotein complexes that control the innate immune response by activating caspase-1, thus promoting the secretion of cytokines in response to invading pathogens and endogenous triggers. Assembly of inflammasomes is induced by activation of a receptor protein. Many inflammasome r...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Sborgi, Lorenzo, Ravotti, Francesco, Dandey, Venkata P., Dick, Mathias S., Mazur, Adam, Reckel, Sina, Chami, Mohamed, Scherer, Sebastian, Huber, Matthias, Böckmann, Anja, Egelman, Edward H., Stahlberg, Henning, Broz, Petr, Meier, Beat H., Hiller, Sebastian
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4629351/
https://ncbi.nlm.nih.gov/pubmed/26464513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1507579112
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