Tau accumulation triggers STAT1‐dependent memory deficits by suppressing NMDA receptor expression

Intracellular tau accumulation forming neurofibrillary tangles is hallmark pathology of Alzheimer's disease (AD), but how tau accumulation induces synapse impairment is elusive. By overexpressing human full‐length wild‐type tau (termed hTau) to mimic tau abnormality as seen in the brain of spor...

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Publicado en:EMBO Rep
Main Authors: Li, Xiao‐Guang, Hong, Xiao‐Yue, Wang, Ya‐li, Zhang, Shu‐Juan, Zhang, Jun‐Fei, Li, Xia‐Chun, Liu, Yan‐Chao, Sun, Dong‐Shen, Feng, Qiong, Ye, Jin‐Wang, Gao, Yuan, Ke, Dan, Wang, Qun, Li, Hong‐lian, Ye, Keqiang, Liu, Gong‐Ping, Wang, Jian‐Zhi
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2019
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549025/
https://ncbi.nlm.nih.gov/pubmed/31085626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201847202
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