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Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins
Intracellular accumulation of tau protein is hallmark of sporadic Alzheimer’s disease (AD), however, the cellular mechanism whereby tau accumulation causes neurodegeneration is poorly understood. Here we report that overexpression of human wild-type full-length tau (termed htau) disrupted mitochondr...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4838862/ https://ncbi.nlm.nih.gov/pubmed/27099072 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24756 |
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