Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2

Cholinergic impairments and tau accumulation are hallmark pathologies in sporadic Alzheimer’s disease (AD), however, the intrinsic link between tau accumulation and cholinergic deficits is missing. Here, we found that overexpression of human wild-type full-length tau (termed hTau) induced a signific...

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Publicado no:Sci Rep
Main Authors: Yin, Yaling, Wang, Yali, Gao, Di, Ye, Jinwang, Wang, Xin, Fang, Lin, Wu, Dongqin, Pi, Guilin, Lu, Chengbiao, Zhou, Xin-Wen, Yang, Ying, Wang, Jian-Zhi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899694/
https://ncbi.nlm.nih.gov/pubmed/27277673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27283
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