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Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2
Cholinergic impairments and tau accumulation are hallmark pathologies in sporadic Alzheimer’s disease (AD), however, the intrinsic link between tau accumulation and cholinergic deficits is missing. Here, we found that overexpression of human wild-type full-length tau (termed hTau) induced a signific...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4899694/ https://ncbi.nlm.nih.gov/pubmed/27277673 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27283 |
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