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Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2

Cholinergic impairments and tau accumulation are hallmark pathologies in sporadic Alzheimer’s disease (AD), however, the intrinsic link between tau accumulation and cholinergic deficits is missing. Here, we found that overexpression of human wild-type full-length tau (termed hTau) induced a signific...

詳細記述

保存先:
書誌詳細
出版年:Sci Rep
主要な著者: Yin, Yaling, Wang, Yali, Gao, Di, Ye, Jinwang, Wang, Xin, Fang, Lin, Wu, Dongqin, Pi, Guilin, Lu, Chengbiao, Zhou, Xin-Wen, Yang, Ying, Wang, Jian-Zhi
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899694/
https://ncbi.nlm.nih.gov/pubmed/27277673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27283
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