Medial septum tau accumulation induces spatial memory deficit via disrupting medial septum–hippocampus cholinergic pathway

Tau accumulation and cholinergic impairment are characteristic pathologies in Alzheimer's disease (AD). However, the causal role of tau accumulation in cholinergic lesion is elusive. Here, we observed an aberrant tau accumulation in the medial septum (MS) of 3xTg and 5xFAD mice, especially in t...

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發表在:Clin Transl Med
Main Authors: Wu, Dongqin, Gao, Di, Yu, Haitao, Pi, Guilin, Xiong, Rui, Lei, Huiyang, Wang, Xin, Liu, Enjie, Ye, Jinwang, Yu, Huilin, Gao, Yang, He, Ting, Jiang, Tao, Sun, Fei, Su, Jingfen, Song, Guoda, Peng, Wenju, Yang, Ying, Wang, Jian‐Zhi
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2021
主題:
Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8161512/
https://ncbi.nlm.nih.gov/pubmed/34185417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ctm2.428
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