Medial septum tau accumulation induces spatial memory deficit via disrupting medial septum–hippocampus cholinergic pathway

Tau accumulation and cholinergic impairment are characteristic pathologies in Alzheimer's disease (AD). However, the causal role of tau accumulation in cholinergic lesion is elusive. Here, we observed an aberrant tau accumulation in the medial septum (MS) of 3xTg and 5xFAD mice, especially in t...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Clin Transl Med
Main Authors: Wu, Dongqin, Gao, Di, Yu, Haitao, Pi, Guilin, Xiong, Rui, Lei, Huiyang, Wang, Xin, Liu, Enjie, Ye, Jinwang, Yu, Huilin, Gao, Yang, He, Ting, Jiang, Tao, Sun, Fei, Su, Jingfen, Song, Guoda, Peng, Wenju, Yang, Ying, Wang, Jian‐Zhi
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2021
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8161512/
https://ncbi.nlm.nih.gov/pubmed/34185417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ctm2.428
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