Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling

Intracellular accumulation of wild-type tau is a hallmark of sporadic Alzheimer’s disease (AD), but the molecular mechanisms underlying tau-induced synapse impairment and memory deficit are poorly understood. Here we found that overexpression of human wild-type full-length tau (termed hTau) induced...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Yin, Yaling, Gao, Di, Wang, Yali, Wang, Zhi-Hao, Wang, Xin, Ye, Jinwang, Wu, Dongqin, Fang, Lin, Pi, Guilin, Yang, Ying, Wang, Xiao-Chuan, Lu, Chengbiao, Ye, Keqiang, Wang, Jian-Zhi
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2016
Materias:
PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932970/
https://ncbi.nlm.nih.gov/pubmed/27298345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604519113
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