Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling

Intracellular accumulation of wild-type tau is a hallmark of sporadic Alzheimer’s disease (AD), but the molecular mechanisms underlying tau-induced synapse impairment and memory deficit are poorly understood. Here we found that overexpression of human wild-type full-length tau (termed hTau) induced...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Yin, Yaling, Gao, Di, Wang, Yali, Wang, Zhi-Hao, Wang, Xin, Ye, Jinwang, Wu, Dongqin, Fang, Lin, Pi, Guilin, Yang, Ying, Wang, Xiao-Chuan, Lu, Chengbiao, Ye, Keqiang, Wang, Jian-Zhi
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2016
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932970/
https://ncbi.nlm.nih.gov/pubmed/27298345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604519113
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