Tau inhibits PKA by nuclear proteasome‐dependent PKAR2α elevation with suppressed CREB/GluA1 phosphorylation

Intraneuronal accumulation of wild‐type tau plays a key role in Alzheimer's disease, while the mechanisms underlying tauopathy and memory impairment remain unclear. Here, we report that overexpressing full‐length wild‐type human tau (hTau) in mouse hippocampus induces learning and memory defici...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Ye, Jinwang, Yin, Yaling, Liu, Huanhuan, Fang, Lin, Tao, Xiaoqing, Wei, Linyu, Zuo, Yue, Yin, Ying, Ke, Dan, Wang, Jian‐Zhi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6974714/
https://ncbi.nlm.nih.gov/pubmed/31668016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13055
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