Promoter Hypermethylation of the Phosphatase DUSP22 Mediates PKA-Dependent TAU Phosphorylation and CREB Activation in Alzheimer's Disease

Genetic screening in Alzheimer's disease (AD) has identified only a handful of genes that are mutated in the disorder. Thus, for a very large proportion of patients, the biology of their disease is poorly understood. Epigenetic alterations may provide an explanation in these cases. Using DNA me...

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Bibliografische gegevens
Gepubliceerd in:Hippocampus
Hoofdauteurs: Sanchez-Mut, Jose Vicente, Aso, Ester, Heyn, Holger, Matsuda, Tadashi, Bock, Christoph, Ferrer, Isidre, Esteller, Manel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Blackwell Publishing Ltd 2014
Onderwerpen:
Rapid Communication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233982/
https://ncbi.nlm.nih.gov/pubmed/24436131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hipo.22245
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