Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins

Intracellular accumulation of tau protein is hallmark of sporadic Alzheimer’s disease (AD), however, the cellular mechanism whereby tau accumulation causes neurodegeneration is poorly understood. Here we report that overexpression of human wild-type full-length tau (termed htau) disrupted mitochondr...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Li, Xia-Chun, Hu, Yu, Wang, Zhi-hao, Luo, Yu, Zhang, Yao, Liu, Xiu-Ping, Feng, Qiong, Wang, Qun, Ye, Keqiang, Liu, Gong-Ping, Wang, Jian-Zhi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838862/
https://ncbi.nlm.nih.gov/pubmed/27099072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24756
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