Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins

Intracellular accumulation of tau protein is hallmark of sporadic Alzheimer’s disease (AD), however, the cellular mechanism whereby tau accumulation causes neurodegeneration is poorly understood. Here we report that overexpression of human wild-type full-length tau (termed htau) disrupted mitochondr...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Li, Xia-Chun, Hu, Yu, Wang, Zhi-hao, Luo, Yu, Zhang, Yao, Liu, Xiu-Ping, Feng, Qiong, Wang, Qun, Ye, Keqiang, Liu, Gong-Ping, Wang, Jian-Zhi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838862/
https://ncbi.nlm.nih.gov/pubmed/27099072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24756
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