Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin

Intracellular accumulation of wild type tau is a hallmark of sporadic Alzheimer's disease (AD). However, the molecular mechanisms underlying tau toxicity is not fully understood. Here, we detected mitophagy deficits evidenced by the increased levels of mitophagy markers, including COX IV, TOMM2...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Hu, Yu, Li, Xia-Chun, Wang, Zhi-hao, Luo, Yu, Zhang, Xiangnan, Liu, Xiu-Ping, Feng, Qiong, Wang, Qun, Yue, Zhenyu, Chen, Zhong, Ye, Keqiang, Wang, Jian-Zhi, Liu, Gong-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper: Gerotarget (Focus on Aging)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951217/
https://ncbi.nlm.nih.gov/pubmed/26943044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7861
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