Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin

Intracellular accumulation of wild type tau is a hallmark of sporadic Alzheimer's disease (AD). However, the molecular mechanisms underlying tau toxicity is not fully understood. Here, we detected mitophagy deficits evidenced by the increased levels of mitophagy markers, including COX IV, TOMM2...

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Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Hu, Yu, Li, Xia-Chun, Wang, Zhi-hao, Luo, Yu, Zhang, Xiangnan, Liu, Xiu-Ping, Feng, Qiong, Wang, Qun, Yue, Zhenyu, Chen, Zhong, Ye, Keqiang, Wang, Jian-Zhi, Liu, Gong-Ping
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2016
Konular:
Research Paper: Gerotarget (Focus on Aging)
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951217/
https://ncbi.nlm.nih.gov/pubmed/26943044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7861
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