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Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin
Intracellular accumulation of wild type tau is a hallmark of sporadic Alzheimer's disease (AD). However, the molecular mechanisms underlying tau toxicity is not fully understood. Here, we detected mitophagy deficits evidenced by the increased levels of mitophagy markers, including COX IV, TOMM2...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4951217/ https://ncbi.nlm.nih.gov/pubmed/26943044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7861 |
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