Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy

Disruption of the dynamic properties of mitochondria (fission, fusion, transport, degradation, and biogenesis) has been implicated in the pathogenesis of neurodegenerative disorders, including Parkinson’s disease (PD). Parkin, the product of gene PARK2 whose mutation causes familial PD, has been lin...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: Van Laar, Victor S., Roy, Nikita, Liu, Annie, Rajprohat, Swati, Arnold, Beth, Dukes, April A., Holbein, Cory D., Berman, Sarah B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322770/
https://ncbi.nlm.nih.gov/pubmed/25478815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.11.015
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados