Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin

Intracellular accumulation of wild type tau is a hallmark of sporadic Alzheimer's disease (AD). However, the molecular mechanisms underlying tau toxicity is not fully understood. Here, we detected mitophagy deficits evidenced by the increased levels of mitophagy markers, including COX IV, TOMM2...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Hu, Yu, Li, Xia-Chun, Wang, Zhi-hao, Luo, Yu, Zhang, Xiangnan, Liu, Xiu-Ping, Feng, Qiong, Wang, Qun, Yue, Zhenyu, Chen, Zhong, Ye, Keqiang, Wang, Jian-Zhi, Liu, Gong-Ping
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2016
Onderwerpen:
Research Paper: Gerotarget (Focus on Aging)
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951217/
https://ncbi.nlm.nih.gov/pubmed/26943044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7861
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