MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration

Macroautophagy/autophagy deficit induces intracellular MAPT/tau accumulation, the hallmark pathology in Alzheimer disease (AD) and other tauopathies; however, the reverse role of MAPT accumulation in autophagy and neurodegeneration is not clear. Here, we found that overexpression of human wild-type...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Autophagy
Main Authors: Feng, Qiong, Luo, Yu, Zhang, Xiang-Nan, Yang, Xi-Fei, Hong, Xiao-Yue, Sun, Dong-Shen, Li, Xia-Chun, Hu, Yu, Li, Xiao-Guang, Zhang, Jun-Fei, Li, Xiao, Yang, Ying, Wang, Qun, Liu, Gong-Ping, Wang, Jian-Zhi
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2019
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7138218/
https://ncbi.nlm.nih.gov/pubmed/31223056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1633862
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki