Phosphorylation of tau antagonizes apoptosis by stabilizing β-catenin, a mechanism involved in Alzheimer's neurodegeneration

Hyperphosphorylated tau is the major protein subunit of neurofibrillary tangles in Alzheimer's disease (AD) and related tauopathies. It is not understood, however, why the neurofibrillary tangle-containing neurons seen in the AD brains do not die of apoptosis but rather degeneration even though...

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Autori principali: Li, Hong-Lian, Wang, Hai-Hong, Liu, Shi-Jie, Deng, Yan-Qiu, Zhang, Yong-Jie, Tian, Qing, Wang, Xiao-Chuan, Chen, Xiao-Qian, Yang, Ying, Zhang, Jia-Yu, Wang, Qun, Xu, Huaxi, Liao, Francesca-Fang, Wang, Jian-Zhi
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1805527/
https://ncbi.nlm.nih.gov/pubmed/17360687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609303104
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