CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer’s Disease

Protein phosphatase 2A (PP2A) inhibition causes hy-perphosphorylation of tau and APP in Alzheimer’s disease (AD). However, the mechanisms underlying the downregulation of PP2A activity in AD brain remain unclear. We demonstrate that Cancerous Inhibitor of PP2A (CIP2A), an endogenous PP2A inhibitor,...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Shentu, Yang-Ping, Huo, Yuda, Feng, Xiao-Long, Gilbert, James, Zhang, Qing, Liuyang, Zhen-Yu, Wang, Xiu-Lian, Wang, Guan, Zhou, Huan, Wang, Xiao-Chuan, Wang, Jian-Zhi, Lu, You-Ming, Westermarck, Jukka, Man, Heng-Ye, Liu, Rong
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095478/
https://ncbi.nlm.nih.gov/pubmed/30021167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.06.009
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