Acetylation of AMPA Receptors Regulates Receptor Trafficking and Rescues Memory Deficits in Alzheimer's Disease

In Alzheimer's disease (AD), decreases in the amount and synaptic localization of AMPA receptors (AMPARs) result in weakened synaptic activity and dysfunction in synaptic plasticity, leading to impairments in cognitive functions. We have previously found that AMPARs are subject to lysine acetyl...

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Bibliographic Details
Published in:iScience
Main Authors: O'Connor, Margaret, Shentu, Yang-Ping, Wang, Guan, Hu, Wen-Ting, Xu, Zhen-Dong, Wang, Xiao-Chuan, Liu, Rong, Man, Heng-Ye
Format: Artigo
Language:Inglês
Published: Elsevier 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7476873/
https://ncbi.nlm.nih.gov/pubmed/32861999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101465
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