CIP2A-promoted astrogliosis induces AD-like synaptic degeneration and cognitive deficits

Reactive astrogliosis and early synaptic degeneration are two characteristic hallmarks in AD brains, but a direct link between the two events has not been established. Here we show that CIP2A, a cancerous protein with high expression level in astrocytes, is upregulated in AD patients and 3xTg-AD tra...

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Detalhes bibliográficos
Publicado no:Neurobiol Aging
Main Authors: Shentu, Yang-Ping, Hu, Wen-Ting, Zhang, Qing, Huo, Yuda, Liang, Jia-Wei, Liuyang, Zhen-Yu, Zhou, Huan, Wei, Hui, Ke, Dan, Wang, Xiao-Chuan, Wang, Jian-Zhi, Man, Heng-Ye, Westermarck, Jukka, Liu, Rong
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6405315/
https://ncbi.nlm.nih.gov/pubmed/30594047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2018.11.023
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