CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer’s Disease

Protein phosphatase 2A (PP2A) inhibition causes hy-perphosphorylation of tau and APP in Alzheimer’s disease (AD). However, the mechanisms underlying the downregulation of PP2A activity in AD brain remain unclear. We demonstrate that Cancerous Inhibitor of PP2A (CIP2A), an endogenous PP2A inhibitor,...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Rep
Egile Nagusiak: Shentu, Yang-Ping, Huo, Yuda, Feng, Xiao-Long, Gilbert, James, Zhang, Qing, Liuyang, Zhen-Yu, Wang, Xiu-Lian, Wang, Guan, Zhou, Huan, Wang, Xiao-Chuan, Wang, Jian-Zhi, Lu, You-Ming, Westermarck, Jukka, Man, Heng-Ye, Liu, Rong
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095478/
https://ncbi.nlm.nih.gov/pubmed/30021167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.06.009
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