Loss of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration and Alzheimer's Disease–Related Tau Phosphorylation Via PAR-1

Abnormal phosphorylation and toxicity of a microtubule-associated protein tau are involved in the pathogenesis of Alzheimer's disease (AD); however, what pathological conditions trigger tau abnormality in AD is not fully understood. A reduction in the number of mitochondria in the axon has been...

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Detalhes bibliográficos
Main Authors: Iijima-Ando, Kanae, Sekiya, Michiko, Maruko-Otake, Akiko, Ohtake, Yosuke, Suzuki, Emiko, Lu, Bingwei, Iijima, Koichi M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431335/
https://ncbi.nlm.nih.gov/pubmed/22952452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002918
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