Ca(2+)/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy

Abnormal deposition of the microtubule-associated protein tau is a common pathological feature of multiple neurodegenerative diseases, including Alzheimer’s disease (AD), and plays critical roles in their pathogenesis. Disruption of calcium homeostasis and the downstream kinase Ca(2+)/calmodulin-dep...

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Detalhes bibliográficos
Publicado no:J Biochem
Main Authors: Oka, Mikiko, Fujisaki, Naoki, Maruko-Otake, Akiko, Ohtake, Yosuke, Shimizu, Sawako, Saito, Taro, Hisanaga, Shin-Ichi, Iijima, Koichi M, Ando, Kanae
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Regular Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892399/
https://ncbi.nlm.nih.gov/pubmed/28992057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jb/mvx038
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