Phosphorylation of tau antagonizes apoptosis by stabilizing β-catenin, a mechanism involved in Alzheimer's neurodegeneration

Hyperphosphorylated tau is the major protein subunit of neurofibrillary tangles in Alzheimer's disease (AD) and related tauopathies. It is not understood, however, why the neurofibrillary tangle-containing neurons seen in the AD brains do not die of apoptosis but rather degeneration even though...

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Detalhes bibliográficos
Main Authors: Li, Hong-Lian, Wang, Hai-Hong, Liu, Shi-Jie, Deng, Yan-Qiu, Zhang, Yong-Jie, Tian, Qing, Wang, Xiao-Chuan, Chen, Xiao-Qian, Yang, Ying, Zhang, Jia-Yu, Wang, Qun, Xu, Huaxi, Liao, Francesca-Fang, Wang, Jian-Zhi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1805527/
https://ncbi.nlm.nih.gov/pubmed/17360687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609303104
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