Phosphorylation of tau antagonizes apoptosis by stabilizing β-catenin, a mechanism involved in Alzheimer's neurodegeneration

Hyperphosphorylated tau is the major protein subunit of neurofibrillary tangles in Alzheimer's disease (AD) and related tauopathies. It is not understood, however, why the neurofibrillary tangle-containing neurons seen in the AD brains do not die of apoptosis but rather degeneration even though...

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Hlavní autoři: Li, Hong-Lian, Wang, Hai-Hong, Liu, Shi-Jie, Deng, Yan-Qiu, Zhang, Yong-Jie, Tian, Qing, Wang, Xiao-Chuan, Chen, Xiao-Qian, Yang, Ying, Zhang, Jia-Yu, Wang, Qun, Xu, Huaxi, Liao, Francesca-Fang, Wang, Jian-Zhi
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1805527/
https://ncbi.nlm.nih.gov/pubmed/17360687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609303104
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