δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer’s disease

δ-Secretase, an age-dependent asparagine protease, cleaves both amyloid precursor protein (APP) and Tau and is required for amyloid plaque and neurofibrillary tangle pathologies in Alzheimer’s disease (AD). However, whether δ-secretase activation is sufficient to trigger AD pathogenesis remains unkn...

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Detalhes bibliográficos
Publicado no:Mol Psychiatry
Main Authors: Zhang, Zhentao, Li, Xiao-Guang, Wang, Zhi-Hao, Song, Mingke, Ping Yu, Shan, Su Kang, Seong, Liu, Xia, Zhang, Zhaohui, Xie, Manling, Liu, Gong-Ping, Wang, Jian-Zhi, Ye, Keqiang
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684859/
https://ncbi.nlm.nih.gov/pubmed/30382187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-018-0286-z
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