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δ-secretase in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities

Mammalian asparagine endopeptidase (AEP) is a cysteine protease that cleaves its protein substrates on the C-terminal side of asparagine residues. Converging lines of evidence indicate that AEP may be involved in the pathogenesis of several neurological diseases, including Alzheimer’s disease, Parki...

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Detalhes bibliográficos
Publicado no:Transl Neurodegener
Main Authors: Zhang, Zhentao, Tian, Ye, Ye, Keqiang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943888/
https://ncbi.nlm.nih.gov/pubmed/31911834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40035-019-0179-3
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