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Activation of the unfolded protein response via inhibition of protein disulfide isomerase decreases the capacity for DNA repair to sensitize glioblastoma to radiotherapy

Patients with glioblastoma multiforme (GBM) survive on average 12–14 months after diagnosis despite surgical resection followed by radiation and temozolomide therapy. Intrinsic or acquired resistance to chemo- and radiation-therapy is common and contributes to a high rate of recurrence. To investiga...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cancer Res
Päätekijät: Liu, Yajing, Ji, Wenbin, Shergalis, Andrea, Xu, Jiaqi, Delaney, Amy M., Calcaterra, Andrew, Pal, Anupama, Ljungman, Mats, Neamati, Nouri, Rehemtulla, Alnawaz
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548663/
https://ncbi.nlm.nih.gov/pubmed/30996048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-2540
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