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Activation of the unfolded protein response via inhibition of protein disulfide isomerase decreases the capacity for DNA repair to sensitize glioblastoma to radiotherapy
Patients with glioblastoma multiforme (GBM) survive on average 12–14 months after diagnosis despite surgical resection followed by radiation and temozolomide therapy. Intrinsic or acquired resistance to chemo- and radiation-therapy is common and contributes to a high rate of recurrence. To investiga...
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| Publicado no: | Cancer Res |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6548663/ https://ncbi.nlm.nih.gov/pubmed/30996048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-2540 |
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