UAE1 inhibition mediates the unfolded protein response, DNA damage and caspase-dependent cell death in pancreatic cancer

The Unfolded Protein Response (UPR) plays a key role in the adaptive response to loss of protein homeostasis within the endoplasmic reticulum (ER). The UPR has an adaptive function in protein homeostasis, however, sustained activation of the UPR due to hypoxia, nutrient deprivation, and increased de...

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Pubblicato in:Transl Oncol
Autori principali: Liu, Yajing, Awadia, Sahezeel, Delaney, Amy, Sitto, Merna, Engelke, Carl, Patel, Heli, Calcaterra, Andrew, Zelenka-Wang, Sylvia, Lee, Hojin, Contessa, Joseph, Neamati, Nouri, Ljungman, Mats, Lawrence, Theodore S., Morgan, Meredith A., Rehemtulla, Alnawaz
Natura: Artigo
Lingua:Inglês
Pubblicazione: Neoplasia Press 2020
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Original article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7369648/
https://ncbi.nlm.nih.gov/pubmed/32688248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2020.100834
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