UAE1 inhibition mediates the unfolded protein response, DNA damage and caspase-dependent cell death in pancreatic cancer

The Unfolded Protein Response (UPR) plays a key role in the adaptive response to loss of protein homeostasis within the endoplasmic reticulum (ER). The UPR has an adaptive function in protein homeostasis, however, sustained activation of the UPR due to hypoxia, nutrient deprivation, and increased de...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Transl Oncol
Egile Nagusiak: Liu, Yajing, Awadia, Sahezeel, Delaney, Amy, Sitto, Merna, Engelke, Carl, Patel, Heli, Calcaterra, Andrew, Zelenka-Wang, Sylvia, Lee, Hojin, Contessa, Joseph, Neamati, Nouri, Ljungman, Mats, Lawrence, Theodore S., Morgan, Meredith A., Rehemtulla, Alnawaz
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Neoplasia Press 2020
Gaiak:
Original article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7369648/
https://ncbi.nlm.nih.gov/pubmed/32688248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2020.100834
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