Inhibition of protein disulfide isomerase in glioblastoma causes marked downregulation of DNA repair and DNA damage response genes

Aberrant overexpression of endoplasmic reticulum (ER)-resident oxidoreductase protein disulfide isomerase (PDI) plays an important role in cancer progression. In this study, we demonstrate that PDI promotes glioblastoma (GBM) cell growth and describe a class of allosteric PDI inhibitors that are sel...

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Bibliografski detalji
Izdano u:Theranostics
Glavni autori: Xu, Shili, Liu, Yajing, Yang, Kai, Wang, Hanxiao, Shergalis, Andrea, Kyani, Anahita, Bankhead, Armand, Tamura, Shuzo, Yang, Suhui, Wang, Xi, Wang, Chih-chen, Rehemtulla, Alnawaz, Ljungman, Mats, Neamati, Nouri
Format: Artigo
Jezik:Inglês
Izdano: Ivyspring International Publisher 2019
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6531306/
https://ncbi.nlm.nih.gov/pubmed/31149044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.30621
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