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Design, Synthesis, and Biological Evaluation of Novel Allosteric Protein Disulfide Isomerase Inhibitors
Protein disulfide isomerase (PDI) is the major enzyme responsible for nascent protein folding in the endoplasmic reticulum (ER) and plays a vital role in glioblastoma progression and survival. To improve the potency of our lead PDI inhibitor BAP2 ((E)-3-(3-(4-hydroxyphenyl)-3-oxoprop-1-en-1-yl)benzo...
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| Publicat a: | J Med Chem |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8276234/ https://ncbi.nlm.nih.gov/pubmed/30759340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01951 |
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