Design, Synthesis, and Biological Evaluation of Novel Allosteric Protein Disulfide Isomerase Inhibitors

Protein disulfide isomerase (PDI) is the major enzyme responsible for nascent protein folding in the endoplasmic reticulum (ER) and plays a vital role in glioblastoma progression and survival. To improve the potency of our lead PDI inhibitor BAP2 ((E)-3-(3-(4-hydroxyphenyl)-3-oxoprop-1-en-1-yl)benzo...

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Bibliografiska uppgifter
I publikationen:J Med Chem
Huvudupphovsmän: Yang, Suhui, Shergalis, Andrea, Lu, Dan, Kyani, Anahita, Liu, Ziwei, Ljungman, Mats, Neamati, Nouri
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8276234/
https://ncbi.nlm.nih.gov/pubmed/30759340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01951
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