PDK1 mediates NOTCH1-mutated head and neck squamous carcinoma vulnerability to therapeutic PI3K/mTOR inhibition

PURPOSE: Head and neck squamous cell carcinoma (HNSCC) is driven largely by the loss of tumor suppressor genes, including NOTCH1, but lacks a biomarker-driven targeted therapy. Although the PI3K/mTOR pathway is frequently altered in HNSCC, the disease has modest clinical response rates to PI3K/mTOR...

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Pubblicato in:Clin Cancer Res
Autori principali: Sambandam, Vaishnavi, Frederick, Mitchell J., Shen, Li, Tong, Pan, Rao, Xiayu, Peng, Shaohua, Singh, Ratnakar, Mazumdar, Tuhina, Huang, Chenfei, Li, Quili, Pickering, Curtis R., Myers, Jeffery N., Wang, Jing, Johnson, Faye M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548600/
https://ncbi.nlm.nih.gov/pubmed/30770351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-3276
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