PDK1 mediates NOTCH1-mutated head and neck squamous carcinoma vulnerability to therapeutic PI3K/mTOR inhibition

PURPOSE: Head and neck squamous cell carcinoma (HNSCC) is driven largely by the loss of tumor suppressor genes, including NOTCH1, but lacks a biomarker-driven targeted therapy. Although the PI3K/mTOR pathway is frequently altered in HNSCC, the disease has modest clinical response rates to PI3K/mTOR...

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Detaylı Bibliyografya
Yayımlandı:Clin Cancer Res
Asıl Yazarlar: Sambandam, Vaishnavi, Frederick, Mitchell J., Shen, Li, Tong, Pan, Rao, Xiayu, Peng, Shaohua, Singh, Ratnakar, Mazumdar, Tuhina, Huang, Chenfei, Li, Quili, Pickering, Curtis R., Myers, Jeffery N., Wang, Jing, Johnson, Faye M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548600/
https://ncbi.nlm.nih.gov/pubmed/30770351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-3276
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