Targeting the Notch1 and mTOR pathways in a mouse T-ALL model

Mutations in NOTCH1 are frequently detected in patients with T-cell acute lymphoblastic leukemia (T-ALL) and in mouse T-ALL models. Treatment of mouse or human T-ALL cell lines in vitro with γ-secretase inhibitors (GSIs) results in growth arrest and/or apoptosis. These studies suggest GSIs as potent...

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Detalhes bibliográficos
Main Authors: Cullion, Kathleen, Draheim, Kyle M., Hermance, Nicole, Tammam, Jennifer, Sharma, Vishva M., Ware, Christopher, Nikov, George, Krishnamoorthy, Veena, Majumder, Pradip K., Kelliher, Michelle A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699237/
https://ncbi.nlm.nih.gov/pubmed/19246562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-02-136762
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