Arginase impairs hypoxic pulmonary vasoconstriction in murine endotoxemia

BACKGROUND: Hypoxic pulmonary vasoconstriction (HPV) optimizes the match between ventilation and perfusion in the lung by reducing blood flow to poorly ventilated regions. Sepsis and endotoxemia impair HPV. We previously showed that nitric oxide synthase 2 (NOS2) is required, but not sufficient, for...

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Bibliografische gegevens
Gepubliceerd in:Respir Res
Hoofdauteurs: Petersen, Bodil, Busch, Cornelius J., Schleifer, Grigorij, Schaack, Dominik, Lasitschka, Felix, Bloch, Kenneth D., Bloch, Donald B., Ichinose, Fumito
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2019
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547543/
https://ncbi.nlm.nih.gov/pubmed/31159807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-019-1062-6
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