Arginase impairs hypoxic pulmonary vasoconstriction in murine endotoxemia

BACKGROUND: Hypoxic pulmonary vasoconstriction (HPV) optimizes the match between ventilation and perfusion in the lung by reducing blood flow to poorly ventilated regions. Sepsis and endotoxemia impair HPV. We previously showed that nitric oxide synthase 2 (NOS2) is required, but not sufficient, for...

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Detalhes bibliográficos
Publicado no:Respir Res
Main Authors: Petersen, Bodil, Busch, Cornelius J., Schleifer, Grigorij, Schaack, Dominik, Lasitschka, Felix, Bloch, Kenneth D., Bloch, Donald B., Ichinose, Fumito
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547543/
https://ncbi.nlm.nih.gov/pubmed/31159807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-019-1062-6
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